Use appropriate caution before using WinSysClean X11 PRO to make Any changes to Windows -- IOW perform a disk partition image backup you know you can restore. The app itself seems pretty straightforward, & adds a more comprehensive list of features than we usually see from cleaning apps, including deleting USB-related registry settings, which is a bit rare.
Windows from time to time will just decide that it's just not going to work anymore with a USB device, usually in my experience a USB stick, plugged into a certain USB port or hub. Microsoft says you can try finding that USB stick in Device Manager and then uninstall it, which may or may not work in my experience. You can also try hunting down references to that USB device in the registry & deleting them, searching on GUIDs & keys etc. you can find in the Details tab of the device's properties in Device Mgr. It's a big PITA but I've had it work. Alternatively you can try GhostBuster -- github[.]com/SPOOCQ/ghostbuster -- or USB Oblivion -- cherubicsoft[.]com/en/projects/usboblivion/ . [Make sure you read the cautions on the USB Oblivion site -- there may be other apps to do the same thing] Purely out of curiosity I tried the USB cleaning in WinSysClean X11 PRO, monitoring what happened in a Win11 VM. On the plus side it saved a .reg file with everything it deleted [in Documents] so you can put things back, but on the minus side I'm really skeptical -- there were a BUNCH of keys deleted that IMHO have absolutely nothing to do with USB sticks or devices.
WinSysClean X11 PRO itself uses an msi installer setup file, so you get a few hundred new registry entries, plus two copies of the setup file are saved. Getting a key was almost instant using a GMail address, but never did arrive using an email at outlook dot com. Besides the program's folder, 2 unusually named folders were added to Users\ [UserName]\ AppData\ Local\ -- one is named IIIQF, while the other is a string of numbers [GUID].