Glary Utilities - oh no not again...
AVG is available for free. If GOTD was going to giveaway an AV product - they could do a LOT better than AVG. But as giveaways do not include updates or support - do you really want antivirus that doesn't include updates?
Perfect Disk - Agree. The best defrag I've come across and I've used ALL of the major products including O&O, Diskeeper, JKDefrag, DirMS and Buzzsaw.
Registry Cleaner - at last count we have seen 200 different registry cleaners offered so far.
Download Manager: Getright? Most of the free download managers are as capable or more so. http://en.wikipedia.org/wiki/Comparison_of_download_managers
Web Design - depending on your needs - the free alternatives are numerous. It really comes down to your experience level and what you are trying to do. Software to create web pages are a dime a dozen.
I think the best products are those that do something new in an innovative way. Something unique. Not 10 different video converters - or 5 different to do lists.
I want to see software that is doing something clever - something that hasn't already been copied and done by everyone else.... you know... same program - different icon.